Welcome To Welox Pharma WHO-GMP | ISO 9001:2015
Translated into:
Welcome To Welox Pharma WHO-GMP | ISO 9001:2015
Indication:
Entecavir is indicated for use in adults with active viral replication and either persistent increases in serum aminotransferases (ALT or AST) or histologically active illness, for the treatment of chronic hepatitis B virus infection.
Action Mechanism:
Entecavir inhibits all three activities of the HBV polymerase (reverse transcriptase, rt) by competing with the natural substrate deoxyguanosine triphosphate: (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger RNA, and (3) synthesis of the positive strand of HBV DNA. When activated by kinases, the drug can be integrated into the DNA, ultimately blocking HBV polymerase activity.
Used:
Entecavir is used to treat chronic (long-term) hepatitis B infection, which is characterized by viral-caused liver swelling. It is prescribed for use in both adults and children. The medication aims to reduce viral replication, alleviate liver inflammation, and contribute to the overall management of chronic hepatitis B. It is important to follow the prescribed dosage and regimen as directed by a healthcare professional. Patients should consult their healthcare providers for comprehensive information regarding the use of Entecavir, including potential side effects, contraindications, and other relevant details.