Introduction to Welnm CS
Welnm CS (Imipenem & Cilastatin Injection 500 mg) is a potent carbapenem antibiotic used for treating severe bacterial infections caused by drug-resistant organisms. Imipenem provides bactericidal activity, while Cilastatin inhibits renal enzyme dehydropeptidase-I, preventing the degradation of Imipenem and ensuring its full antibacterial potential. This combination is widely used in intensive care and hospital settings for managing life-threatening infections.
Uses of Welnm CS
Complicated intra-abdominal infections
Lower respiratory tract infections, including hospital-acquired pneumonia
Complicated urinary tract infections, including pyelonephritis
Severe skin and soft tissue infections
Bacteremia and septicemia
Gynecological infections, including postpartum endometritis
Bone and joint infections caused by resistant bacteria
Benefits of Welnm CS
Broad-spectrum coverage against Gram-positive, Gram-negative, and anaerobic bacteria
Effective against multi-drug resistant (MDR) pathogens
Cilastatin enhances Imipenem’s stability and efficacy
Rapid bactericidal action for critical infections
Used in serious hospital-acquired infections and ICU settings
Mechanism of Action of Welnm CS
Imipenem inhibits bacterial cell wall synthesis, leading to cell death. Cilastatin prevents renal degradation of Imipenem, ensuring higher drug levels in the bloodstream and prolonged antibacterial action. This combination ensures maximal effectiveness against resistant bacterial strains, making it a preferred choice for serious infections.