Welcome To Welox Pharma WHO-GMP | ISO 9001:2015
Translated into:
Welcome To Welox Pharma WHO-GMP | ISO 9001:2015
Introduction to I-Stat Imipenem And Cilastatin Injection
I-Stat Imipenem And Cilastatin Injection, offered by Lexaro Healthcare, combines Imipenem and Cilastatin to provide a robust treatment for severe bacterial infections. This formulation is designed to deliver high efficacy in treating life-threatening infections by maximizing the therapeutic potential of Imipenem while minimizing its renal metabolism through the action of Cilastatin.
Uses of I-Stat Imipenem And Cilastatin Injection
I-Stat is primarily used for:
Treating complicated urinary tract infections caused by susceptible bacteria.
Managing intra-abdominal infections, including peritonitis and abscesses.
Treating severe pneumonia, including hospital-acquired and ventilator-associated pneumonia.
Managing bacterial septicemia and endocarditis.
Treating skin and soft tissue infections, including diabetic foot infections.
Managing bone and joint infections.
Benefits of I-Stat Imipenem And Cilastatin Injection
Broad-Spectrum Antibiotic: Effective against a wide range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains.
Combination Therapy: Cilastatin enhances the efficacy of Imipenem by preventing its renal degradation.
High Efficacy: Provides robust and rapid action against severe bacterial infections.
Reduced Resistance Risk: Combination therapy reduces the risk of developing antibiotic resistance.
Comprehensive Treatment: Suitable for treating a variety of serious infections, offering versatile therapeutic options.
Mechanism of Action of I-Stat Imipenem And Cilastatin Injection
Imipenem and Cilastatin, the active ingredients in I-Stat, work by:
Inhibiting Cell Wall Synthesis: Imipenem binds to penicillin-binding proteins (PBPs) on bacterial cell walls, inhibiting the final step of peptidoglycan synthesis, which is essential for bacterial cell wall integrity. This leads to cell lysis and death of the bacteria.
Preventing Degradation: Cilastatin inhibits dehydropeptidase I, an enzyme in the kidneys that would otherwise degrade Imipenem. By inhibiting this enzyme, Cilastatin ensures higher concentrations of Imipenem in the body, enhancing its antibacterial activity.
Broad-Spectrum Activity: Imipenem is effective against a wide range of bacteria, including both aerobic and anaerobic, Gram-positive and Gram-negative organisms. This broad-spectrum activity makes it useful for treating mixed infections and severe infections where the causative organism is not immediately known.